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Skip to contentName: IGF-1 LR3 (Insulin-Like Growth Factor-1 Long R3)
Category: Recombinant peptide, Research Use Only (Not for Human or Veterinary Use)
Source: Recombinant expression system (typically in E. coli)
Appearance: Lyophilized (freeze-dried) white powder
Molecular Formula: C₄₀₀H₆₂₅N₁₁₁O₁₁₅S₉
Molecular Weight: ~9,100 Da
Amino Acids: 83 (Modified form of human IGF-1 with a substitution at position 3 and additional amino acids for extended half-life)
CAS Number: 946870‑92‑4
Use Case: In vitro research, metabolic studies, muscle growth research, cell culture applications
Not Approved For: Human therapeutic use, non-clinical applications
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IGF‑1 LR3 is a synthetic analogue of the natural hormone Insulin‑like Growth Factor‑1 (IGF‑1) — a protein involved in growth, muscle development, and cellular repair. In IGF‑1 LR3, one amino acid is substituted (arginine in position 3) and 13 extra amino acids are added on its end, which:
Makes it more potent than normal IGF‑1
Extends its activity in the body much longer (≈20–30 hours) than native IGF‑1’s ~12‑15 hour half‑life
This modification increases how long the peptide stays active and how effectively it binds to IGF‑1 receptors, enhancing its biological effects compared with regular IGF‑1.
IGF‑1 LR3 is typically supplied as a research peptide and is not approved for therapeutic use in humans — many sources emphasize that it’s intended for research or clinical investigation, not general consumption or sports performance enhancement.
Name: IGF-1 LR3 (Insulin-Like Growth Factor-1 Long R3)
Category: Recombinant peptide, Research Use Only (Not for Human or Veterinary Use)
Source: Recombinant expression system (typically in E. coli)
Appearance: Lyophilized (freeze-dried) white powder
Molecular Formula: C₄₀₀H₆₂₅N₁₁₁O₁₁₅S₉
Molecular Weight: ~9,100 Da
Amino Acids: 83 (Modified form of human IGF-1 with a substitution at position 3 and additional amino acids for extended half-life)
CAS Number: 946870‑92‑4
Use Case: In vitro research, metabolic studies, muscle growth research, cell culture applications
Not Approved For: Human therapeutic use, non-clinical applications
Purity:
Typically ≥98% pure by SDS-PAGE and HPLC analysis
Bioactive form verified via receptor binding assays, showing effective IGF-1 receptor interaction
Common purity standards ≥99% in high-end products
Endotoxin levels typically <0.01 EU/μg for high-grade preparations
Bioactivity:
IGF-1 LR3 shows a significant increase in protein synthesis, enhancing muscle cell growth, recovery, and proliferation
Assayed activity: EC₅₀ (effective concentration) value demonstrated in cell proliferation assays
Extended half-life (~20-30 hours) compared to native IGF-1 (~12-15 hours)
Cell growth enhancement verified in muscle culture assays
Lyophilized Powder:
Long-term storage: Store at -20°C to -80°C (freezer) in a dry, dark, and airtight container
Short-term storage: Can remain stable at 2°C to 8°C for up to 6 months
Avoid direct exposure to moisture or light; keep sealed with desiccant
Reconstituted Solution:
Upon reconstitution, store at 2°C to 8°C for up to 7 days
Freeze in single-use aliquots for long-term storage
Avoid freeze-thaw cycles as they degrade the peptide
Lyophilized Powder:
Long-term storage: Store at -20°C to -80°C (freezer) in a dry, dark, and airtight container
Short-term storage: Can remain stable at 2°C to 8°C for up to 6 months
Avoid direct exposure to moisture or light; keep sealed with desiccant
Reconstituted Solution:
Upon reconstitution, store at 2°C to 8°C for up to 7 days
Freeze in single-use aliquots for long-term storage
Avoid freeze-thaw cycles as they degrade the peptide